HPE ProLiant DL380 Gen10 Plus 2U Rackmount Server

Four factory chassis decide what an HPE ProLiant DL380 Gen10 Plus can hold, and that choice is fixed at order time rather than in the field. HPE documents no field upgrade from the eight-bay large-form-factor chassis to a twelve-bay front end, so the front end is settled once and for all. Expansion is bound to the same decision, because the rear large-form-factor cages consume every slot on the riser behind them.

The rest of the platform is gated by the processor. Thirty-two DIMM slots exist but only sixteen are usable with one processor fitted, memory speed is set by the processor model rather than by the module, and the high-performance heatsink becomes mandatory at 150 W and above. Slots four through eight sit on risers driven by the second processor, so a single-processor build has three PCIe slots and no route to more. Networking has no default either: none ship standard, and an OCP or stand-up card is a required selection.

DL380 Gen10 Plus chassis options and what each one commits you to

Four CTO front ends exist for the DL380 Gen10 Plus, and a50002553enw lists them as distinct chassis types rather than as variants of one machine. The eight-bay small-form-factor chassis is the flexible one: it takes the Universal Media Bay P14609-B21, an eight-bay mid tray and up to six rear bays, and extends to twenty-four front bays with added cages.

Two cells there change what a build costs. The twenty-four-bay and twelve-bay models already include six high-performance fans, so kit P14608-B21 is not a line to add on either. And the eight-bay chassis ships with a SAS/SATA cage in bay 3: swapping it for NVMe or Tri-Mode needs the Bay 3 Cage Removal FIO Option 873763-B21 first, so a quote without it counts bay 3 twice.

Processors, memory and power on the DL380 Gen10 Plus are one linked decision

The DL380 Gen10 Plus carries 32 DIMM slots - sixteen per processor, eight channels per processor, two DIMMs per channel - reaching 8.0 TB with thirty-two 256 GB load-reduced modules at 3200 MT/s or 2.0 TB with thirty-two 64 GB registered modules. The figure listings get wrong is the speed: the ceiling is a property of the processor, not of the module.

Three rules follow. Silver 43xx parts and the Gold 6338N cap at 2667 MT/s and the Gold 6330 and 5320 at 2933, so 3200 MT/s modules in a Silver build run slower than the label. The U-suffix parts carry no dual-socket support, dropping usable slots to sixteen. And processors ship without heatsinks: P27095-B21 is required at 150 W and above, P37034-B21 below it.

Eight power supplies are documented and mixing two different ones is not allowed, so a redundant pair means two of the same part. Our lineup census carries an incomplete row here, omitting both 800 W direct-current variants and the 1600 W direct-current supply, so the QuickSpecs list is the one to quote against.

Cooling is the Standard Fan Kit P37042-B21 or the Maximum Performance Fan Kit P14608-B21, six fans that fill all six cages. Because the twelve-bay and twenty-four-bay models already ship with six high-performance fans, that kit is a real line item only on the eight-bay chassis, where it becomes mandatory the moment an accelerator is fitted.

Storage, risers and accelerators on the DL380 Gen10 Plus all draw on the same PCIe slots

Three PCIe slots are available on a single-processor DL380 Gen10 Plus and eight on a two-processor build, because slots four through eight sit on the secondary and tertiary risers and both are driven by the second processor. That collides with storage directly: HPE's note is that the two-bay large-form-factor rear cages consume all PCIe slots on the primary and secondary riser respectively.

Every cached controller needs a backup part, and HPE names two: the Smart Storage Hybrid Capacitor P02377-B21 or the Smart Storage Battery P01366-B21. A cached Smart Array bought second-hand without one runs with write cache disabled. Maximum internal storage runs to 397.8 TB with small-form-factor SAS drives, 385.92 TB with NVMe and 360 TB with large-form-factor SAS or SATA.

Seven accelerators are listed and the ceiling on each is set by what else occupies the risers. The H100 NVL 94 GB S2D86C is capped at one and permits no other card on the primary riser and no rear drive cage; the H100 80 GB R9S41C reaches two but blocks both risers. The L4, A10 and A16 are all excluded from the twelve-bay chassis. Mixing accelerator types is never allowed, and every one requires the Maximum Performance Fan Kit and the High Performance Heat Sink Kit.

Where the DL380 Gen10 Plus sits in the ProLiant lifecycle

The DL380 Gen10 Plus is marked RETIRED in HPE's QuickSpecs banner, which means the base products are no longer available for sale from HPE. The document identifier is a50002553enw and HPE last revised it at version 42, dated 28 July 2025. The earliest revision recorded in our lineup census is dated 6 April 2021, which makes that a floor rather than a launch date HPE publishes.

Two other Gen10 Plus documents were revised as late - the DL360 Gen10 Plus at version 44 and the DL385 Gen10 Plus v2 at version 30, both the same day - and a vendor still revising a retired product's specification is the clearest public signal of a large installed base in service. HPE publishes no support-end date for this platform on any public surface, and none appears here.

DL380 Gen10 vs DL380 Gen10 Plus vs DL380 Gen11

Three DL380 generations circulate in the aftermarket at once, and the difference between them is memory architecture before anything else. The Gen10 is a 24-slot DDR4 machine at 2933 MT/s. The Gen10 Plus keeps DDR4 and moves to 32 slots at 3200 MT/s. The Gen11 moves to 32 slots of DDR5 and adds an EDSFF front end the older two do not have.

The Gen10 Plus is a memory upgrade rather than a compute one; the Gen11 is a platform change. The trap is that the chassis names are identical on all three, so a listing that says only 24SFF says nothing about which generation is in the box. The reliable tells are the processor generation and the DIMM slot count. The DL380 Gen10 still has the deepest parts pool of the three.

Choosing within the Gen10 Plus ProLiant line

The DL380 Gen10 Plus is the two-socket 2U Intel member of that line, so the choice against its siblings is about height, socket count and processor family. Three comparisons outside the line are live in our catalogue: the DL380 Gen10, its 1U counterpart the DL360 Gen10, and the tower ML350 Gen10.

Buying a refurbished DL380 Gen10 Plus

Four specifics belong on a quote. The chassis, because there is no field upgrade from eight to twelve large-form-factor bays. The processor count, because sixteen DIMM slots and five PCIe slots are wired to the second socket. The network adapter, because none ships standard. And the cache backup module, because a cached Smart Array without one runs with write cache disabled. Out-of-band management is HPE Integrated Lights-Out, licensed per server against an order rather than welded to a chassis.

Virtualization is the workload this platform is most often bought for, and both paths are available: VMware ESXi is the incumbent across a large share of 3rd generation Xeon estates, and Proxmox Virtual Environment is the alternative Enterasource sells outright as an authorized reseller, with subscriptions and support on the same order as the hardware. Enterasource builds each unit to the specification ordered, testing on receipt, then disassembling, cleaning, inventorying, picking, assembling, configuring and testing again on the bench. Whole systems carry the 2-year Enterasource warranty, and shipping is free to the lower 48 states. Browse the HPE ProLiant server range, or the Dell PowerEdge range where the same processor generation appears as the PowerEdge R750.

Frequently Asked Questions

What are the HPE ProLiant DL380 Gen10 Plus specifications?

Two sockets for 3rd generation Intel Xeon Scalable processors to 40 cores each, 32 DDR4 DIMM slots at sixteen per processor, a maximum of 8.0 TB load-reduced or 2.0 TB registered at 3200 MT/s, four front chassis covering 8SFF, 24SFF, 8LFF and 12LFF, and three PCIe slots with one processor rising to eight with two.

How much memory does the DL380 Gen10 Plus support?

The stated maximum is 8.0 TB from thirty-two 256 GB load-reduced modules at 3200 MT/s, or 2.0 TB from thirty-two 64 GB registered modules. A single-processor build is limited to sixteen slots and half that capacity. Achievable speed is set by the processor: Silver 43xx parts cap at 2667 MT/s, the Gold 6330 and 5320 at 2933.

Which chassis options does the DL380 Gen10 Plus come in?

Four: an eight-bay small-form-factor chassis, a twenty-four-bay small-form-factor chassis reaching thirty-eight drives, an eight-bay large-form-factor chassis, and a twelve-bay large-form-factor chassis reaching twenty. The eight-bay model is the only one taking the Universal Media Bay, and HPE documents no field upgrade from eight to twelve large-form-factor bays.

Is a DL380 Gen10 Plus worth the step up from a DL380 Gen10?

It is a memory step rather than a compute one, so it depends on what the workload is short of. The Gen10 has 24 DDR4 slots capped at 3.0 TB load-reduced or 1.54 TB registered at 2933 MT/s; the Gen10 Plus has 32 slots capped at 8.0 TB or 2.0 TB at 3200 MT/s on 3rd generation Xeon Scalable. Chassis names and rack height are identical on both.

Where do I find the DL380 Gen10 Plus QuickSpecs, and is the platform still sold?

The document identifier is a50002553enw, at version 42 dated 28 July 2025, and HPE marks its banner as retired, meaning the base products are no longer available for sale from HPE. Quoting that identifier by name is the reliable way to be given the current revision rather than a mirrored copy. HPE publishes no support-end date on any public surface, so none is quoted here.